- The Student Government Association (SGA): The SGA serves as an advisory body to all chartered student organizations and clubs. SGA provides a forum for the exchange of ideas among members of the student body. Meetings are held every Wednesday at noon.
- 4 Seasons Club: Love the great outdoors? Skiing, snowboarding, horseback riding, hiking, camping, white-water rafting? We are the club for you!
- Blue and White Society: We are the student members of the Penn State Alumni Association. We provide opportunities to network with alumni, hold the Annual Blue and White Ball, and more.
- Business Club: New York City... here we come! Join us for our etiquette dinner, professional speakers, and our annual trip to the Big Apple.
- Gender and Sexuality Alliance: An alliance of students, faculty and staff, the purpose of this group is to create a welcoming, non-judgmental, and confidential space for LGBTQ+ and straight ally students, staff and faculty of Penn State Wilkes-Barre.
- Honor Society: Penn State Wilkes-Barre Honors Society provides a means for motivated students to enrich their general education and to deepen their specialized preparation for employment or graduate study. In addition to succeeding and performing in the classroom, honors students participate in a variety of cultural and personal enrichment activities, such as volunteering, fund-raising, supporting diversity programs, and experiencing different cultures and economies. Some past events include trips to Toronto, Montreal, Williamsburg, Washington DC, and New York City.
- Just Amazing Musicians (JAM): Like music? Play an instrument? Like to sing? Join us!
- Lambda Sigma: We are the National Honor Society of surveying majors.
- Lion Ambassadors: We are the official student representatives and tour guides of Penn State Wilkes-Barre. Join us and learn to walk backwards!
- The Nerd Herd: We are a club for every fandom (Dr. Who, Zenkaikon, ComiCon, and more)...Find your Nerd and let it out!
- Radio Club: Got Talent? Open mic events, deejaying in the Student Commons, car shows, and more!
- The Revolt: Got News? Journalism major? Become a reporter and write for the campus paper.
- Students For Justice: Do you like watching Criminal Minds or CSI? Anyone with interest in the justice system is encouraged to join. We work on bringing to light criminal justice issues while also seeking to advance the concept of justice through community activities and campus projects.
- STEAM Club: Science, Technology, Engineering, Arts and Math.
- Surveying Society: Geocache, anyone? Lime green vests? We provide opportunities for our members to hear guest speakers, participate in field trips, and attend state and national professional conferences.
- Sustainability Council: An alliance of students, faculty and staff, the purpose of this group is to create a campus community that prioritizes sustainability. Primary to this mission is the education of campus and community members.
- Penn State Wilkes-Barre Benefitting THON Committee: FTK... For the Kids! The largest student-run philanthropy in the world, THON is a year-long effort to raise funds and awareness for the fight against pediatric cancer, culminating in a 48-hour dance marathon to raise money for the Four Diamonds Fund at the Hershey Medical Center. Help us help them!
- United Stance Society: Explore, promote, and increase the awareness of various cultural and religious groups on campus and in our community.
- Veterans Support Club (VSC): We are a group of veterans, ROTC, active-duty, reservist, and supporters who work to support and raise awareness of veterans on campus. Additionally, we look to assist veterans within the local community.